Eutectic Mixtures to Enhance the Solubility of Active Pharmaceutical Ingredients: Density Functional Theory and Infrared Spectroscopy Approaches
نویسندگان
چکیده
The major issue with active pharmaceutical ingredients (APIs) is their slow dissolution rate and solubility. This makes them less likely to get into the body bioavailable. About 40 % of drugs already on market 90 being made have APIs that do not dissolve well in water. To deal this problem, authors designed eutectic mixture (EMs) different (danazol, griseofulvin, mefenamic acid, tolfenamic acid tadalafil) zinc chloride; studied interaction thermodynamic parameters using Density Functional Theory (DFT) computation. DFT calculations confirm an increase dipole moment EMs comparison alone which increases change Gibbs free energy formation gaseous phase shows feasibility ans stability.
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ژورنال
عنوان ژورنال: ChemistrySelect
سال: 2023
ISSN: ['2365-6549']
DOI: https://doi.org/10.1002/slct.202300824